Palmitoylethanolamide, commonly referred to as PEA, is a naturally occurring fatty acid amide synthesized within our bodies. It plays a crucial role in the biological mechanisms related to pain and inflammation, functioning within a class of substances that act on nuclear receptors to exert their effects.

Also Known As

Palmitoylethanolamide is widely recognized for its therapeutic potential, particularly in managing pain and inflammation. It is commonly referred to by various names, including:

  • Palmidrol


PEA has found its application primarily in the health and wellness industry, serving both as a dietary supplement and as a component in medical foods. In countries like Italy and Spain, it is available in specific dosages designed for medical purposes, highlighting its significance in managing conditions related to chronic pain and inflammation.


Palmitoylethanolamide stands out in the realm of pain management and anti-inflammatory treatments due to its unique action mechanism involving nuclear receptors. This endogenous compound has been the subject of various studies, underscoring its potential in offering a natural therapeutic pathway for individuals suffering from chronic pain and inflammation-related conditions.

  • Naturally produced in the body, PEA is involved in combating inflammation and pain.
  • It binds to a specific nuclear receptor, influencing a broad range of biological functions.
  • Used as a supplement and for medical purposes in certain European countries.

Common Dosage

The common dosage of Palmitoylethanolamide varies depending on its use. As a dietary supplement, the dosage typically is 400 mg in capsule form. For medical applications, particularly in Italy and Spain, PEA is available in tablets of 300 mg and 600 mg.


Palmitoylethanolamide (PEA) represents a significant advancement in the understanding and management of pain and inflammation. Its ability to naturally interact with nuclear receptors in the body offers a promising pathway for therapeutic intervention without relying on conventional medications. The availability of PEA in various dosages as supplements and for medical purposes underscores its versatility and efficacy in managing chronic pain and inflammatory conditions.

  • A natural compound with significant anti-inflammatory and pain-relief properties.
  • Available in dosages suitable for supplements and specific medical applications in Europe.
  • Offers a therapeutic alternative with a unique mechanism of action.

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